Molecular and Cellular Pharmacology, Vol 9, No 1 (2017)

Protein Kinase D: A Potential Therapeutic Target in Prostate Cancer

Abstract

Protein kinase D (PKD) belongs to a family of serine/threonine kinases in the calcium/calmodulin-dependent kinase superfamily. It modulates a number of signal transduction pathways involved in regulation of cell proliferation, survival, migration, angiogenesis, regulation of gene expression, and protein/membrane trafficking, mediated by variety of stimuli such as growth factors, hormones, and cellular stresses. Although its role in cancer progression remains elusive, current literature supports a potential tumor promoting function of the selective PKD isoforms in prostate cancer, making them promising therapeutic targets for cancer treatment.

Keywords: Prostate cancer; Protein kinase D; Signal transduction; Therapeutic target.

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